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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbationsassociated with severe obstructive airway disease (SOSA). Background: Most chronic obstructive pulmonary disease (COPD) is associated with moderate to severe airway hyperresponsiveness that is associated with chronic high airway pressure, which may result in the development of COPD exacerbations (COPD exacerbations are those of extreme distress or of clinically significant medical importance), including airway obstruction (AIR) and lung injury, steroids uk flu. COPD exacerbations are generally classified according to the presence of specific signs and symptoms of respiratory distress, pulmonary edema, reduced air volume, and acute severe exacerbation of COPD with the most severe manifestations of respiratory distress and severe lung injury. There is evidence that asthma and inflammatory bowel disease are associated with chronic COPD, suggesting that these diseases may contribute in some way to increased risk from adverse effects of inhaled corticosteroids in COPD, steroids uk legal status. More research is clearly required to investigate the potential benefits of inhaled corticosteroids in COPD, which may help to reduce the burden of these respiratory diseases, steroids uk limited. Methods: This was a systematic review and meta-analysis to summarize the effectiveness and safety of inhaled corticosteroids in moderate to severe obstructive airway disease (SOSA) associated with severe airway hyperresponsiveness. A primary end point was the proportion of participants who experienced significant or moderate reduction in symptoms or airway obstruction following treatment with inhaled corticosteroids for SOSA associated with severe airway hyperresponsiveness, steroids uk limited. Secondary efficacy end points for each of the studies were analyzed by meta-analysis, rhino roids review. All analyses were conducted using Stata with the software package "Stata 11" (Stata Corp LP, College Station, TX). Publication bias was assessed by a two‐sided P value, and effect sizes were calculated with an inverse variance, Wald and Fisher exact tests, steroids uk flu. Results: Ten studies were included. Three of these studies were double‐blind, placebo‐controlled trials (one was a placebo‐controlled, double‐blind trial), and one was a crossover study, the steroid shop. Twelve of the studies were multicenter, double‐blind, crossover trials. Most studies were double‐blind, placebo‐controlled studies. The overall number of participants was 487, with a mean duration of study of 7, roids review rhino.4 years, roids review rhino. The mean weight loss observed in all studies was 4.8%, or 7.8 kg.

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